| For over
30 years Christopher J. Thompson has been an innovator advancing
the design and development of PET imaging systems, making significant
contributions that have shaped the way in which PET systems operate
to this day. In 1978 he and his team constructed the first BGO-based
PET system, the Positome II, which demonstrated that BGO was a viable
scintillator for PET applications and had significant sensitivity
gains as compared with NaI(Tl) based detectors. For the 20 years
following this work BGO remained the premier scintillator for PET
imaging applications.
In 1994, Chris published the first paper describing the concept
of Positron Emission Mammography (PEM) based on two planar detectors
positioned above and below the breast. This work led to the construction
of a prototype PEM system integrated with an x-ray mammography unit
and formed the basis for the PEM Flex system manufactured by Naviscan
PET Systems. This device was the first high-resolution PET system
designed specifically for imaging small body parts to obtain FDA
clearance.
Chris has continuously worked to improve PET image quality through
both hardware and software solutions. By recognizing that spatial
under-sampling leads to reduced spatial resolution, he first worked
on detector ring wobbling techniques to improve spatial sampling
and later developed depth-of-interaction capable detectors to improve
spatial sampling with a stationary ring. Patient motion in PET studies
is a major source of error and loss of resolution. In response to
this, he developed techniques for correcting for subject motion
in PET scanning by triggering new acquisition frames when the subject
moved. Chris was among the first to demonstrate the utility of now
commonly used Monte Carlo simulation techniques in PET. The PETSIM
Monte Carlo package he developed was used successfully by his and
other groups to optimize PET system designs. Chris realized that
out-of-field activity degraded the quality of brain PET studies
through increased randoms counts. To counter this problem, he developed
the "NeuroShield" to reduce the effects of out-of-field
activity and demonstrated a 35% increase in the noise equivalent
count rate for brain studies. Most recently, Chris developed a timing
alignment probe to aid in the timing calibration of time-of-flight
PET systems, which is very relevant given the recent clinical introduction
of TOF systems.
Throughout his career, Chris has published nearly 100 peer reviewed
papers and holds 10 patents related to PET imaging. In his 30 years
as a faculty member at McGill University he has supervised 24 master's
and Ph.D. students, most of whom have gone on to work in imaging
technology development or as medical physicists.
Chris Thompson retired from McGill last year and is now a post-retirement
professor. He continues to work on PET detectors in his basement
in Montreal, Canada. Email: christopher.thompson@mcgill.ca
Katsuyuki ‘Ken’
Taguchi
Young Investigator Medical Imaging Award
Katsuyuki "Ken" Taguchi is unique in that
he has made significant scientific contributions in the development
of algorithms for cardiac, multi-slice, and four-dimensional x-ray
CT imaging in both industry and academia. After receiving his Master
of Science from Tokyo Institute of Technology in 1991, Ken joined
Toshiba where he remained until 2005. His work on the multi-slice
CT project began in 1994 and he very quickly began work on algorithms
that were incorporated into the 4-, 8-, 16-, and 64-slice x-ray
CT scanners developed by Toshiba. In one of his first projects,
he developed an algorithm for multi-slice CT in which cone-beam
data could be reformulated into reconstructions of a stack of fan
beam geometries. He was one of the first to propose the use of multi-slice
CT for cardiac imaging developing an algorithm that used projections
only during the cardiac phase of interest. These works were published
in Medical Physics. In 1998-2000, Ken spent a year and a half at
the University of Utah as a visiting scientist. It was during this
time that Toshiba introduced their first multi-slice CT scanner
(4 slices) implementing both of Ken’s published algorithms
in this scanner. While in Utah, he developed a cone beam reconstruction
algorithm that reformatted helical cone beam data into Radon planar
integrals using a combination of spherical harmonics and Grangeat’s
formulation. In 2000, he returned to Japan where he continued working
full time for Toshiba. Working long hours at Toshiba and at the
same time trying to finish his Ph.D. thesis, he implemented cone
beam algorithms of the extended Feldkamp-type in the Toshiba 8-,
and 16-slice scanners. Ken finished his Ph.D. thesis in 2002 and
moved to Chicago to work for Toshiba America Medical Systems where
he developed a direct cone beam reconstruction algorithm that was
implemented in the Aquilion64 for cardiac imaging. The algorithm
was able to eliminate the characteristic banding artifact seen in
the multi-slice CT cardiac images. In 2005, Ken moved on to Johns
Hopkins University to join the Medical Physics Group of Benjamin
Tsui, Ph.D. where he has continued to work on x-ray CT algorithms.
His motion correction algorithm developed with Professor Kudo was
published in IEEE Transactions on Medical Imaging in 2008. His present
projects include: time-resolved cardiac 4D CT imaging, CT imaging
with photon counting x-ray detectors, and quantitative interventional
tumor oncology using C-arm CT imaging. He is presently Assistant
Professor of Radiology at Johns Hopkins University and is funded
by NIH, American Heart Association, and Siemens. In addition to
his impressive record of peer viewed publications (15), Ken has
25 US patents and 90 Japanese patents.
Katsuyuki "Ken" Taguchi can be reached at Johns Hopkins
University, Department of Radiology, 601 North Caroline Street,
JHOC 4253A, Baltimore, MD 21287. 433-287-2974. ktaguchi@jhmi.edu.
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